NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a genetic small vessel disease (SVD) caused by heterozygous variants in the NOTCH3 gene (Joutel et al., 1996; Sharma et al., 2001).