Polyphenolic natural products, including quercetin (Le et al., 2020), curcumin (Liu et al., 2017), resveratrol (Mota et al., 2020), baicalin (Yang et al., 2019), can regulate microglia polarization by inhibiting TLR4/NF-κB pathway, leading to anti-inflammatory roles in ischemic stroke (Li et al., 2022). This evidence concerns the gene TLR4 and ischemic stroke.