Polyphenolic natural products, including quercetin (Le et al., 2020), curcumin (Liu et al., 2017), resveratrol (Mota et al., 2020), baicalin (Yang et al., 2019), can regulate microglia polarization by inhibiting TLR4/NF-κB pathway, leading to anti-inflammatory roles in ischemic stroke (Li et al., 2022). The gene discussed is NFKB1; the disease is ischemic stroke.