Tanshinol borneol ester (DBZ) promotes the transformation of microglia from the M1 to M2 phenotype by activating the Akt/GSK-3β/NRF2 pathway and releasing a series of anti-inflammatory and antioxidant factors to protect against cerebral ischemia (Liao et al., 2020). Here, GSK3B is linked to brain ischemia.