This study reveals reasons of survival improvement in patients with HCC with a high expression of FDX1 from two sides: Immune infiltration is high and PD-1 expression is low in the patients with HCC with a high expression of FDX1; a high FDX1 expression reduces tumor prefiltration and migration abilities through the cuproptosis pathway. The gene discussed is PDCD1; the disease is hepatocellular carcinoma.