SLC2A1 and breast cancer: Vincristine and bortezomib suppressed GLUT-1 and HK expression to induce apoptosis in MM cells (73), while WZb117 and phloretin inhibited GLUT-1 activity to decrease glucose uptake with synergistic anti-tumor effects in leukemia, lung, colon and breast cancers (74, 89, 90).