At the same time, the expression of M2 macrophage-related genes from normal tissues and tumors of different individuals was analyzed, and the results showed that there was a difference in VSIG4, TMEM144, SLC40A1, LIPA, CRYBB1, COLEC12, FUCA1, BCAT1 between tumor tissues and normal tissues (Supplementary Figure 3). The gene discussed is COLEC12; the disease is neoplasm.