VSIG4 and neoplasm: The ROC curve confirmed that our prognostic model has high accuracy in predicting survival, which means that M2 macrophages in TAMs play a key role by affecting model genes, including SLC40A1, VSIG4, FUCA1, LIPA, BCAT1, CRYBB1, F13A, TMEM144 and COLEC12, in tumor cells of patients with renal cell carcinoma.