In addition, the differences in the expression of M2 macrophage-related genes between tumor tissues and paracancerous tissues from the same sample were analyzed, and the results showed that there were differences in the expression of VSIG4, TMEM144, SLC40A1, LIPA, CRYBB1, COLEC12, FUCA1 and BCAT1 between tumor tissues and paracancerous tissues (Supplementary Figure 2). Here, CRYBB1 is linked to neoplasm.