BRD2 and polycystic ovary syndrome: Multivariate linear regression analysis showed that FSH was an independent risk factor (β = 0.284, p = 0.009) for the increase of BMAT in overweight and obese PCOS patients even after adjusting for age, BMI, and LDL-C (Table 4), while estradiol was an independent protecting factor (β = -0.226, p = 0.039).