Dipeptidyl peptidase 4 (DPP4), an adipokine released by hepatocytes, is known to be upregulated in the liver of patients with obesity and NAFLD, while methylated DPP4 is negatively correlated with the stages of hepatic steatosis and NASH (131). The gene discussed is DPP4; the disease is obesity due to melanocortin 4 receptor deficiency.