All SNPs in TM6SF2, GCKR, MBOAT7 and HSD17B13 are shown to be associated with PNPLA3 I148M, affecting all stages of NAFLD, suggesting that these genetic variants have additive effects on the progression of NAFLD and NAFLD-related HCC (84). This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.