Accumulating evidence reveals that obesity accelerates the secretion of hepatokines from hepatocytes such as hepassocin (HPS), angiopoietin-like protein 8 (ANGPTL8), Fetuin-A and B and fibroblast growth factor 19 and 21 (FGF19/21) (109, 110). The gene discussed is ANGPTL8; the disease is obesity disorder.