BGN and metabolic dysfunction-associated steatohepatitis: During the last decades, diverse non-invasive blood testing has been developed, plasma biomarkers (e.g. high-density lipoprotein cholesterol (HDL-C), biglycan (BGN), cytokeratin 18 (CK18), pro collagen III (Pro-C3) and plasma N-terminal propeptide of type III procollagen (PIIINP)) are commonly used to reflect specific and complex molecular mechanisms underlying the pathogenesis and progression of NAFLD and NASH (154, 223).