Single nucleotide polymorphisms (SNPs) in genes, including human patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulator (GCKR), membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), are associated with NASH development and they are associated with regulation of hepatic fat content, plasma liver enzyme levels and glucose metabolism (116, 117). Here, TM6SF2 is linked to metabolic dysfunction-associated steatohepatitis.