ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: Accumulating evidence reveals that obesity accelerates the secretion of hepatokines from hepatocytes such as hepassocin (HPS), angiopoietin-like protein 8 (ANGPTL8), Fetuin-A and B and fibroblast growth factor 19 and 21 (FGF19/21) (109, 110).