The C-C chemokine receptors 2 and 5 (CCR2 and CCR5) and their respective ligands (CCL2 and CLL3-5) are implicated in the pathogenesis of liver inflammation, immune cell infiltration and fibrosis, leading to the development of NAFLD and NASH (114). This evidence concerns the gene CCR5 and metabolic dysfunction-associated steatohepatitis.