A recent study found that activation of the SIRT3-SOD2-GPX4 signaling pathway, including upregulation of sirtuin 3 (SIRT3) expression, inhibition of superoxide dismutase 2 (SOD2) acetylation, and consequently promotion of GPX4 expression, helped restore mitochondrial redox homeostasis, thereby alleviating ferroptosis in DN models (118). The gene discussed is GPX4; the disease is liver dysplastic nodule.