Apart from levels of calcium, serum creatinine, total immunoglobulins (IgG, IgA, or IgM), hemoglobin, and total serum proteins, bone lesions at presentation were also included, as they has been described as the most common CRAB symptom (hypercalcemia, renal insufficiency, anemia, and bone lesions) in MM [8]. This evidence concerns the gene CD40LG and hypercalcemia disease.