CCL5 and systemic lupus erythematosus: Besides, Fan et al. (2010) found that the application of HDH could significantly inhibit the expression of regulated on activation, normal T cell expressed and secreted (RANTES, also known as C-C motif chemokine 5), a biomarker of LN (Das and Brunner, 2009), in serum and renal tissue of MRL/lpr mice (lupus-prone mice).