TNF and lobular neoplasia: TNF signaling pathway (Aten et al., 2000), Toll-like receptor signaling pathway (Pawar et al., 2007), NF-kappa B signaling pathway (Su et al., 2018), HIF-1 signaling pathway (Chen et al., 2020c), and PI3K-Akt signaling pathway (Stylianou et al., 2011) represent classic signaling pathways of LN.