In this study, by applying the systematic integrated network pharmacology method to traditional Chinese medicine research, our analyses identified TNF, VEGFA and JUN as the most pivotal therapeutic targets of HDH against LN (Figures 7B, C), with the binding of the former two proteins with their corresponding HDH components being validated by molecular docking, especially the interaction between stigmasterol and TNF (Figures 7D–G, Table 1). Here, JUN is linked to lobular neoplasia.