In mucosal immune response, interleukin-22 (IL-22) upregulates mucin, fibrinogen and anti-apoptotic protein; therefore, IL-22 may contribute to the formation of life-threatening edema, and the lungs may be rich in mucin and fibrin, leading to the progress of ARDS (Wu and Yang, 2020). The gene discussed is IL22; the disease is acute respiratory distress syndrome.