AKT1 and neoplasm: In another study by Man GCW et al., in 2020, the apoptotic effects of a prodrug of (−)-epigallocatechin-3-gallate (ProEGCG, 20, 40, 60 μM) showed a highly anti-proliferative activity on tumor cells in both EC xenografts cultured in vivo and RL95–2 and AN3 CA EC cells in vitro via promoting apoptosis, which was associated with activation of Akt, Up-regulating caspase-3, PARP, JNK, p38 whereas down-regulating ERK (Man et al., 2020).