MTOR and cancer: Signaling pathways determined by PI3K, AKT, and the mammalian target of rapamycin (mTOR) are critical for many features of cancer, such as cell growth, survival, metabolism, apoptosis, and angiogenesis (Ediriweera et al., 2019; Fattahi et al., 2020; Miricescu et al., 2020; Mirza-Aghazadeh-Attari et al., 2020).