In addition, our results showed that JCF could also inhibit the proliferation of HBV-related hepatoma cells via an HBx-dependent manner, and the key genes were enriched for cancer-related pathways, including the PI3K-Akt pathway, proteoglycans in cancer, microRNAs in cancer, and pathways in cancer. This evidence concerns the gene AKT1 and hepatocellular carcinoma.