CASP8 and neoplasm: Supplementary Table S1; Figure 1A present detailed information for the Venn diagram. Five ICD-related genes were preliminarily identified. Next, we performed a correlation analysis and found that the genes CASP8 and DNM1L had the strongest correlation (Figure 1B). The results of differential expression between tumor and normal tissues are shown in Figure 1C. In the TCGA database, all five genes exhibited significant differences. The GO enrichment analysis indicated that these differentially expressed genes were mainly enriched in cellular transition metal ion homeostasis (Figure 1D).