The other central AD hypothesis focuses on the neurofibrillary pathology, initiated by the pathological misfolding and aggregation of tau protein (Braak and Braak, 1991; Fernández et al., 2008; Maccioni et al., 2010), resulting in synaptic loss, axonal retraction, and neuronal death (Wang and Mandelkow, 2016). This evidence concerns the gene MAPT and Alzheimer disease.