For INSTI drugs, patients had a higher risk of neurological diseases when they had an exposure (odds ratio [OR]:1.25, 95% confidence interval [CI]:1.06–1.46), history of current exposure (OR: 1.38, 95% CI: 1.14–1.66), low cumulative DDDs (< 305) (OR: 1.64, 95% CI: 1.34–2.01), and low adherence [0 < adherence (ADH) ≤ 0.8] (OR: 1.38, 95% CI: 1.17–1.63) (Table 6). Here, AVP is linked to nervous system disorder.