Studies also showed that the ETBF promoted colon tumorigenesis via a toxin called B. fragilis toxin (BFT) and interleukin (IL)-17 in colon epithelial cells through the recruitment of myeloid cells to the tumor microenvironment (TME), which led to the differentiation of myeloid cells into inducible nitric oxide synthase (iNOS) hi monocytic myeloid-derived suppressor cells (Mo-MDSCs). This evidence concerns the gene NOS2 and neoplasm.