Since abnormal accumulation of CD206+ M2 macrophages and profibrotic TECs are key points for accelerating the transition from AKI to CKD (Cao et al., 2015; Venkatachalam et al., 2015; Wang et al., 2017; Feng et al., 2018; Tang et al., 2019), we further examined whether the SGK3/TOPK signaling pathway was linked to renal failure recovery. The gene discussed is SGK3; the disease is Renal insufficiency.