Finally, we discovered that the 12 IMRGs expression had significant differences, among which SFXN3, TFR2, TMPRSS6, HMOX1, and LCN2 expressions were elevated in the cancer group, and SCARA5, LTF, STEAP2, SLC39A14, CP, ALAS2, and TF were low expressed in the tumor group (Fig. 2A). This evidence concerns the gene TFR2 and cancer.