Significantly, it is becoming increasingly evident that NLRP1 dysfunction is also associated with skin‐related genetic disorders such as NAIAD (NLRP1‐associated autoinflammation with arthritis and dyskeratosis), systemic sclerosis, multiple self‐healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC).18, 19, 20. Here, NLRP1 is linked to systemic sclerosis.