BDNF and schizophrenia: Kimhy et al. [59] conducted a RCT of a pre-immersive VR active video game (Xbox 360 Kinect, Your Shape Fitness evolved 2012 Ubisoft) to examine the impact of aerobic exercise on neurocognitive function and brain-derived neurotrophic factor (BDNF) regulation in 33 patients with schizophrenia.