Disorders of androgen synthesis:a.Insensitivity to LH (Leydig cell aplasia/hypoplasia)b.7-dehydrocholesterol reductase deficiency (Smith–Lemli–Opitz syndrome)c.Star protein deficiency (lipoid congenital adrenal hyperplasia)d.Cholesterol desmolase deficiencye.3β-hydroxy steroid dehydrogenase type 2 deficiencyf.17α-hydroxylase/17–20 desmolase deficiencyg.P450-oxidoreductase deficiencyh.Cytochrome B5 deficiencyi.Defective backdoor pathway adrenal steroidogenesisj.17β-hydroxy steroid dehydrogenase type 3 deficiencyk.5α-reductase type 2 deficiencyl.Isolated hypospadias and/or cryptorchidism. Here, PLOD1 is linked to hypospadias.