IL22 and colitis: The LNP was composed by phosphatidicacid, monogalactosyldiacylglycerol, and digalactosyldiacylglycerolat the molar ratio of 5:2:3, and the mRNA loaded LNP was with around200 nm diameter and −18 mV of surface charge.26 Oral administration of IL-22 mRNA loaded LNP significantlyincreased the expression of IL-22 in the colonic mucosa and acceleratedthe healing of colitis in mouse models, evidenced by the recoveryof body weight and colon length.