In another study, Huang et al. use a novel LNPto deliver mRNAencoded with bispecific T-cell engaging (BiTE) antibody B7H3-CD3,which could bind with B7H3 receptors on tumor cells and CD3 receptorson T cells simultaneously, thereby inducing the recognition of tumorcells by T cells and antitumor efficacy.63 The LNP was composed of DMG-PEG, DSPC, cholesterol, and an ionizablecationic lipid IC8, with a size of 118 nm and a surface charge of10 mV. This evidence concerns the gene CD276 and neoplasm.