The abundant extracellular matrix (ECM) in the tumormicroenvironmentgreatly restricts drug delivery to deep tumor cells, which usuallyleads to treatment failure.60 The activationof focal adhesion kinase (FAK) involves in the formation of denseECM.61 To solve this problem and enhancethe delivery efficiency of LNP to the tumor, Zhang et al. preparedan LNP loaded with Cas9 mRNA, PD-L1 sgRNA, and FAK siRNA.62 The cationic component used in this LNP is 5A2-SC8,which is an ionizable amino lipid dendrimer that facilitates the endosomeescape of LNP. Here, CD274 is linked to neoplasm.