HNF4A and liver disorder: Yang et al. developed an mRNA-loaded LNP to deliver mRNAto the liver.48 The protein encoded bymRNA was human hepatocyte nuclear factor alpha (HNF4A), a promisingcandidate for attenuation of liver fibrosis.49,50 This LNP could successfully induce the production of HNF4A in fibroticmurine or human hepatocytes and strongly inhibit fibrogenesis infour kinds of liver fibrosis mouse models after intravenous injection.This research work broadens the application of mRNA LNP in liver diseases.