Hence, we performed a western blotting assay and found that downregulation of SDR16C5 decreased Bcl-2, cleaved-caspase 3, and cleaved-caspase 9 protein expression and increase Bax expression, suggesting that SDR16C5 is responsible for the inhibition of apoptosis in PAAD. The gene discussed is CASP3; the disease is pancreatic adenocarcinoma.