As presented in Figure 5, SDR16C5 expression was significantly associated with B cells (CD38 r = −0.21, P = 0.0044; CD79A r = −0.16, P = 0.036), CD8 + T cells (CD8A r = −0.27, P = 0.00025; CD8B r = −0.25, P = 0.00079), T cell follicular helper (ICOS, r = −0.21, P = 0.0057) and dendritic cells (HLA-DPB1 r = −0.26, P = 0.00043; HLA-DRA r = −0.16, P = 0.031; HLA-DPA1 r = −0.16, P = 0.027; CD1C r = −0.2, P = 0.0074) in PAAD. This evidence concerns the gene ICOS and pancreatic adenocarcinoma.