This 3.7 Mb genomic region contains a cluster of four interferon (IFN) receptor (IFNR) genes: Ifnar, Ifnar2, Ifngr2, and Il10rb. In addition, genetic variants in human IFNGR2 and IL10RB have been associated with CHDs in DS from two cohort studies composed of 198 individuals and 702 individuals, respectively.20 Here, IFNAR2 is linked to Dravet syndrome.