IL10RB and Dravet syndrome: This 3.7 Mb genomic region contains a cluster of four interferon (IFN) receptor (IFNR) genes: Ifnar, Ifnar2, Ifngr2, and Il10rb. In addition, genetic variants in human IFNGR2 and IL10RB have been associated with CHDs in DS from two cohort studies composed of 198 individuals and 702 individuals, respectively.20