EDN1 and type 2 diabetes mellitus: One example of such a translatable test is the Tübingen–Boston Rat Coma Scale (RCS) developed by Pais-Roldán et al. (2019) who used an endothelin-1 injection to cause brain infarctions and induce coma, after which the animals were analysed for behavioural outcomes in the acute stages of coma recovery.