Once the spike (S) protein of SARS-CoV-2 binds to the cell receptors, pattern-recognition receptors such as Nod-like receptor (NLR) or absent in melanoma-2 (AIM2) will assemble inflammasomes through inducing membrane pore formation and activation of proinflammatory cytokines in order to activate cell death and eliminate the viral infection (Figure 1). Here, AIM2 is linked to viral infectious disease.