Our study supports the weak association between MOGAD and tumors, since: (a) the prevalence of neoplasms in a cohort of patients with MOGAD is low, (b) oncological accompaniments are extremely variable and MOG is usually not expressed in neoplastic tissue, (c) most of reported cases do not fulfill the criteria of PNS; (d) there are no striking features that could distinguish cases with possible/probable PNS from those with non-PNS, with the notable exception for a trend favoring the presence of ovarian teratoma in the first group (Figure 2). This evidence concerns the gene MOG and paraneoplastic neurologic syndrome.