CALR and peeling skin syndrome: For example, the Sjögren’s Big Data Project of 10,500 patients reports that patients diagnosed with anti-Ro/SSA or anti-La/SSB antibodies have lower mean age at the time of diagnosis and a higher frequency of constitutional, renal, cutaneous, or hematological manifestations, which suggest that seronegative pSS may be a milder form of the disease (11).