NFE2L2 and cancer: Estrogenic activityAnti-oxidant (via ER receptors, modulates NO release via Akt, attenuates ER stress via Nrf2)Anti-cancer (via Akt pathway, via mitophagy)Cardioprotective effect (improves arterial stiffness)Anti-diabetic (via cAMP pathway and preventing GLP-1 secretion)