ESR1 and myocardial ischemia: Alleviates myocardial ischemia/reperfusion injury (via PI3K/Akt pathway)Anti-cancer (via estrogen receptors)Anti-inflammatory (via AhR and NF-kB pathway inhibition)Anti-oxidantIncreases mitophagy (via PINK1-Parkin) and mitochondrial functionIncreases skeletal muscle function (via Sirtuin1 and Pgc1a)