Given that the Dctn1-IR1 and Dred-IR1 transgenic constructs we identified were sufficient to decrease the respective transcript levels to a high degree, we asked whether loss of function of either Dctn1 or Dred in disease-relevant tissues leads to an impairment in motoric ability, which is considered as the most obvious outward feature of ALS. This evidence concerns the gene NISCH and amyotrophic lateral sclerosis.