The contribution of muscle tissue to ALS pathophysiology is supported by various studies in animal models (Loeffler et al., 2016; Anakor et al., 2022) including Drosophila, where for instance, motor abnormalities that overlap with those described here were reported on muscle-selective disruption of TDP-43, which is itself found aggregated in the majority of ALS patients (Diaper et al., 2013). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.