PPM1D and malignant glioma: As an example, the combination of lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy has been shown to eradicate malignant glioma (Wang et al., 2016), and PPM1D inhibitors can enhance the anti-proliferative and pro-apoptotic effects of ionizing radiation in diffuse intrinsic pontine glioma (Akamandisa et al., 2019).