DNMT3A and acute myeloid leukemia: Cohesin complex mutations (RAD21, STAG1, STAG2, SMC1A, and SMC3) have been observed in approximately 13% of patients with AML.88Cohesin complex mutations demonstrate the arrangement of collective exclusivity but are accompanied by NPM1, TET2, DNMT3A, and RUNX1 mutations.