RUNX1 is a transcription factor that regulates the differentiation and growth of hematopoietic stem and progenitor cells.52, 53It is intermittently translocated to RUNX1T1 and shows an advantageous prognosis.54, 55RUNX1 point mutation has been observed in 5 to 13% of cases of AML. This evidence concerns the gene RUNX1 and acute myeloid leukemia.