In many patients having AML, ASXL1 mutations are either nonsense or frameshift mutations.24, 25, 26, 27Mutations in ASXL1 are jointly privileged to FLT3-ITD and NPM1 and participate with IDH1/2, TET2, RUNX1, and EZH2.28Currently, ASXL1 mutant protein has been recognized to perform a necessary performance in leukemogenesis and myeloid differentiation in virtue of BAP1. This evidence concerns the gene RUNX1 and acute myeloid leukemia.