The intracellular and extracellular SPINK2 expression in AML cell lines (median: 0.074 ng/mg, range: 0.95–1.04 ng/mg and median: 3.85 ng/mg, range: 0.05–0.30 ng/mg, respectively) also significantly increased compared to non-AML cell lines (median: 0.056 ng/mL, range:0.05–0.079 ng/mL and median: 0.004 ng/mL, range: 0–0.02 ng/mL, respectively) (p=0.036 and p=0.023, respectively). The gene discussed is SPINK2; the disease is acute myeloid leukemia.