We were found that the expression of SPINK2 mRNA was higher in AML cell lines (median: 10.5 AU, range: 8.72–12,32 AU) than non-AML cell lines (median: 0.9 AU, range: 0.41–3.41 AU) using Mann-Whitney U test (p=0.036). This evidence concerns the gene SPINK2 and acute myeloid leukemia.