SPINK2 mRNA levels in patients with AML (median: 1.62 AU, range: 0.0032–28.67 AU) were significantly higher than in controls (median: 0.058 AU, range: 0.00017–1.51 AU), which showed that SPINK2 expression was significantly up-regulated in AML (p=0.004) (Figure 1). The gene discussed is SPINK2; the disease is acute myeloid leukemia.