More recently, a biflavonoid fraction from Garcinia madruno, that was composed of morelloflavone (65%), volkensiflavone (12%), GB 2a (11%), fukugiside (6%) and amentoflavone (0.4%) demonstrated neuroprotective activity in a transgenic mouse model of Alzheimer’s disease (e.g. reduced deposition of Aβ particles, β-secretase-mediated cleavage of amyloid precursor protein, tau pathology, astrogliosis and microgliosis). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.