Knee osteoarthritis that was induced by DMM (destabilization of the medial meniscus) exhibited the dissociation of TrkA and Cbl-b E3 ligase in dorsal root ganglion (DRG) neurons, leading to impaired Cbl-b-mediated degradation of TrkA, thereby contributing to TrkA-dependent pain sensitization (49). This evidence concerns the gene CBLB and osteoarthritis, knee.