By analysis of exosomes produced by macrophages and M1-like macrophages after digoxin treatments, this study found that digoxin governed inflammatory microenvironment of osteoarthritis and enhanced chondrogenesis via inhibition of the synovial macrophage M1-like polarization and exosomal miR-146b-5p, USP3 and SOX5 pathways in osteoarthritis (128). The gene discussed is USP3; the disease is osteoarthritis.