Furthermore, DNAM-1-CD3ζ engineered NK cells were particularly more effective to recognize and kill two NB cell lines, LAN-5 and SMS-KCNR, treated with Nutlin-3a, an MDM2 targeting drug with immunomodulatory effects on the upregulation of ligands for NK cell-activating receptors, including PVR and Nectin-2 (47). Here, CD226 is linked to neuroblastoma.