NFE2L2 and colorectal cancer: The literature shows that many medicinal plants and phytochemicals, synthetic chemicals or inducers, and others, such as metformin and short-chain fatty acids, modulate the effects of Nrf2 on UC and UC-associated colorectal cancer by activating Nrf2-mediated antioxidant expression and attenuating NF-κB-associated inflammation (Table 1).