It was observed that systemic administration of PEGylated human IL-10 (pegilodecakin) promotes infiltration, activation and intratumor expansion of tumor-specific CD8+ T cells and restores their cytotoxic activity, resulting in enhanced granzyme B and IFN-γ production in CD8+ cells, enhanced intratumor antigen presentation and induction of anti- tumor immune response with evidence of clinical benefits in different advanced solid tumors, such as renal cell carcinoma and uveal melanoma (112, 191, 197, 198). This evidence concerns the gene CD8A and neoplasm.