Although the exact function played by IL-10 in COVID-19 has not yet been fully defined, due to the multifaceted actions exerted on inflammation, IL-10 has been increasingly proposed as critical contributor during the kinetics of cytokine storm, which is considered a main responsible for the development and progression of ARDS in COVID-19 patients and a keystone factor in influencing disease morbidity and mortality (211, 212, 259). This evidence concerns the gene IL10 and COVID-19.