In addition, some non-immune cell types, including intestinal epithelial cells, intestinal fibroblasts and skin keratinocytes, produce IL-10 in response to certain stimuli, comprising infection, UV radiation, tissue injury and damage (83–86), and even different tumor cells, such as melanoma, breast and colon carcinoma cells, have demonstrated IL-10 secretion ability (87–90). Here, IL10 is linked to colon carcinoma.