On the other hand, IL-10 mediates important tumor-inhibiting activities by recruiting and stimulating cytotoxic CD8+ T cells and NK cells in the tumor microenvironment, by promoting lymphocyte and antibody-dependent immune memory, by abrogating inflammatory M1 macrophage-Th17 T cells axis, by downregulating the synthesis of pro-angiogenic factors and by suppressing local release of pro-inflammatory cytokines that support tumor growth, survival, and invasion (167, 184–188). This evidence concerns the gene IL10 and neoplasm.