AGT and Hypertension: Viral entry into cells mediates the downregulation of ACE2 and its consequent failure to convert the angiotensin II into angiotensin 1-7, resulting in the accumulation of angiotensin II and overstimulation of RAAS that ultimately causes hypertension, electrolyte unbalancing, lung fibrosis and inflammation, vasculitis, thromboembolism and intravascular disseminated coagulation (207, 249).