EREG and neoplasm: Importantly, we observed that these results are in agreement with in vivo data from CRC patients, such as LRP5, CXCL8 and EREG. In particular, LRP5, a member of the Wnt pathway (45), which presents the highest increase in its expression in macrophages upon CRC co-culture, is overexpressed in tumor-associated macrophages (TAMs) in CRC patients.