LRP5 and colorectal carcinoma: LRP5 is poorly expressed in M1 macrophages, but it is induced upon co-culture with CRC as shown by the Volcano plot (Figure 1D), by the heatmap (Figure 1E), by the Integrative Genomics Viewer (IGV) of the 3’RNA-Seq and Chromatin bound RNA-Seq (ChrRNA-Seq) data (Figure 1F), and by the increase in LRP5 protein levels (Figure 1G).