Furthermore, several other genes in the 35 gene DGE signature presented by macrophages after co-culture with CRC (from Figure 1E), including EREG, CXCL8, IL1B, ARL4C, ARMC9, BAIAP2, F2RL2, GP1BA, MT-TP and P2RY13, show the same expression profile in TAMs from CRC patients (Figure 2B and Supplementary Figure S3). The gene discussed is EREG; the disease is colorectal carcinoma.