As these cell lines differ in several tumorigenic markers such as APC, K-ras, B-raf, TGFBR2 and MLH1 (38), the identification of these new mRNA isoforms in response to CRC cells may provide insight on the crosstalk and signaling occurring between CRC cells and macrophages. This evidence concerns the gene TGFBR2 and colorectal carcinoma.