After exposure to CRC cells for 24 hours, we identified our macrophage expression profile as belonging to the inflammatory cytokine-enriched TAMs (G0S2, IL1B, IL6, S100A8) and pro-angiogenic TAMs (HES1, IL1B, IL8, S100A8, SERPINB2, THBS1). This evidence concerns the gene SERPINB2 and colorectal carcinoma.