Our 3’RNA-Seq data yields the biggest known catalog to date of differential usage of alternative 3’ UTRs and IPAs in primary human macrophages after M1 polarization, CRC stimuli and SRSF12 knockdown, consisting of 30584 total 3’UTR-APA and IPA events, of which 1161 show significant differences. Here, SRSF12 is linked to colorectal carcinoma.