In addition to the cytogenetic prognostic value, some genetic mutations were identified as independent predictors of survival including focal IKZF1 gene deletion in B-ALL and the absence of NOTCH1/FBXW7 mutation and/or N/K-RAS mutation and/or PTEN gene alteration in T-cell ALL (23). This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.