Also, under treatment with AMD plasma, ARPE-19 cells showed increased secretion of pro-inflammatory cytokines IL-1, IL-6, IL-8, MCP-1, and the angiogenic factor VEGF-A; among them, the secretion of MCP-1 and VEGF-A was the highest. The gene discussed is CXCL8; the disease is age-related macular degeneration.