According to a previous report in a Chinese population (19), HLA DR3, DR4, DR9, DRB1*0901-DQA1*05-DQB1*0201, DRB1*0301-DQA1*03-DQB1*0303, and DRB1* 0405-DQA1*03-DQB1*0401 were categorized as T1D susceptible haplotypes, while DRB1*1101-DQA1*05-DQB1*0301, DRB1*0803-DQA1*0103-DQB1*0601, DRB1*1202-DQA1*0601-DQB1*0301, DRB1*1501-DQA1*0102-DQB1*0602 and DRB1*1401-DQA1*0101-DQB1*0503 were recognized as protective haplotypes. This evidence concerns the gene TNFRSF25 and type 1 diabetes mellitus.