As shown in Table 2, DR9 and DRB1*0405-DQA1*03-DQB1*0401 are the major T1DM susceptible haplotypes, whereas DRB1*1101-DQA1*05-DQB1*0301 and DRB1*1202-DQA1*0601-DQB1*0301 are the major T1DM protective haplotypes in ICI-DM. This evidence concerns the gene HLA-DRB1 and diabetes mellitus.