O-GlcNAcylation is one of the most sensitive and dynamic posttranslational modifications (PTMs), which is catalyzed by O-GlcNAc transferase (OGT) and eliminated by O-GlcNAcase (OGA), and modulates a myriad of cellular events, including the host immune response and signal transduction during pathogen infection (18–20). This evidence concerns the gene OGA and infection.