AFP and hepatocellular carcinoma: Multivariable Cox regression analysis indicated two variables to closely associated with RFS in HCC patients with HRRFs: AFP ≥ 400 ng/mL (HR: 2.28, 95% CI: 1.27-4.11, P = 0.006) and PAT (HR: 0.33, 95% CI: 0.18-0.60, P < 0.001) (Table S2).