HSPA5 and cancer: Recently, SCNN1B was found to inhibit the growth and metastasis of gastric cancer cells, and the expression level of SCNN1B was positively correlated with the survival rate of gastric cancer patients and reduce the expression level of Glucose-Regulated Protein 78 [GRP78, Recent studies have also found that GRP78 expression is elevated in cancer cells and plays an important role in the development of cancer tumors (30, 31)].