ADH7 and gastric cancer: In conclusion, the present study screened and validated the key genes ADH7, CWH43 and SCNN1B, which are significantly associated with GC development, based on the GEO public database, through a combination of WGCNA and lasso regression models, providing a molecular basis for the early diagnosis and treatment of GC, as well as for immunotherapy research and the development of new targeted drugs.