This integrative approach identified candidate causal genes at 20 AD risk loci, including AP4E1, AP4M1, APBB3, BIN1, MS4A4A, MS4A6A, PILRA, RABEP1, SPI1, TP53INP1 and ZYX. The study suggests that some loci might have multiple target genes co-regulated by enhancer-associated AD variants at the same locus. The gene discussed is AP4E1; the disease is Alzheimer disease.