This integrative approach identified candidate causal genes at 20 AD risk loci, including AP4E1, AP4M1, APBB3, BIN1, MS4A4A, MS4A6A, PILRA, RABEP1, SPI1, TP53INP1 and ZYX. The study suggests that some loci might have multiple target genes co-regulated by enhancer-associated AD variants at the same locus. This evidence concerns the gene MS4A4A and Alzheimer disease.