IGHE and asthma: When we compared patients with an asthma severity score of <2 with those with asthma severity scores of 2-4 regarding IgE binding frequency and IgE levels to Blo t 5 and HDM allergens, we found that patients with more severe asthma reacted more often to Blo t 5 and to HDM allergens than patients with a low asthma severity score (Figure 7).