MYOM2 and AL amyloidosis: They can be detected in serum or urine as a monoclonal component (MC) or paraprotein, also known as protein M. The clinical spectrum is wide, including classical malignancies such as multiple myeloma (MM) or Waldenström macroglobulinemia, clonal paraprotein-related diseases such as light chain amyloidosis, and premalignant plasma cell dyscrasia, called monoclonal gammopathy of undetermined significance (GMSI/MGUS) [1].