SETD2 gene mutations have been identified in many cancers including kidney cancer (Cancer, 2013), pancreatic cancer (Niu et al., 2020a), prostate cancer (Yuan et al., 2020), leukemia (Dong et al., 2019), lung adenocarcinoma (Zhou Y et al., 2020), brain glioma (Fontebasso et al., 2013), breast cancer (Morcillo-Garcia et al., 2019), and gastrointestinal cancer (Chen et al., 2018). The gene discussed is SETD2; the disease is familial pancreatic carcinoma.